• Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L

       Zhu C​, Iwase M, Li Z, Wang F, Quinet A, Vindigni A, Shao J.

       Nature Communications 2022 Nov 1; 13, 6531. doi: 10.1038/s41467-022-34310-9

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• Phospho-Ser784-VCP Drives Resistance of Pancreatic Ductal Adenocarcinoma to Genotoxic Chemotherapies and Predicts the Chemo-Sensitizing Effect of VCP Inhibitor

       Wang F, Vij K, Li L, Dodhiawala P, Lim KH, Shao J.

       Cancers (Basel) 2021 Oct 11;13(20):5076.

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• Ser71 Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity

       Wang F*, Zhu C*, Cai S, Boudreau A, Kim S*, Bissell M, Shao J.

       Front. Cell Dev. Biol. 2021 June 21, 9:692269. * Equal authorship

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• Cancer-Associated Exportin-6 Upregulation Inhibits the Transcriptionally Repressive and Anticancer Effects of Nuclear Profilin-1

      Zhu C*, Kim S*, Mooradian A, Wang F, Li Z, Holohan S, Collins P, Wang K, Guo Z, Hoog J, Ma CX, Oltz EM, Held JM, Shao J.

      Cell Rep 2021 February 16, 34(7): 108749. * Equal authorship

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• Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

       Shao J

       Mol Cell Oncol. 2020 Aug 12; 7(5):1796179

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• Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

      Zhu C*, Rogers A*, Asleh K*, Won J, Gao D, Leung S, Li S, Vij KR, Zhu J, Held JM, You Z, Nielsen TO, Shao J

      Cell Rep 2020 Jun 9; 31(10): 107745. * Equal authorship

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• Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer                                                                Lei JT*, Shao J*, Zhang J*, Iglesia M*, Chan DW, Cao J, Anurag M, Singh P, He X, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, Ramalho S, Peres RMR, Punturi N, Schmidt C, Bartram A, Jou E, Devarakonda V, Holloway KR, Lai WV, Hampton O, Rogers A, Tobias E, Parikh PA, Davies SR, Li S, Ma CX, Suman VJ, Hunt KK, Watson MA, Hoadley KA, Thompson EA, Chen X, Kavuri SM, Creighton CJ, Maher CA, Perou CM, Haricharan S, Ellis MJ

      Cell Rep 2018 Aug 7;24(6):1434-1444.e7. * Equal authorship

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• Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets                   Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE Oncogene 2018 Aug;37(33):4581-4598.

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• Breast tumors educate the proteome of stromal tissue in an individualized but coordinated manner
  Wang X, Mooradian AD, Erdmann-Gilmore P, Zhang Q, Viner R, Davies SR, Huang KL, Bomgarden R, Van Tine BA, Shao J, Ding L, Li S, Ellis MJ, Rogers JC, Townsend RR, Fenyo D, Held JM
  Sci Signal 2017 Aug 8;10(491). pii: eaam8065.

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• Efficacy of SERD/SERM hybrid-CDK4/6 inhibitor combinations in models of endocrine therapy-resistant breast cancer
  Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder R, Lai JP, Norris JD, McDonnell DP, Li S
  Clin Cancer Res 2015 Nov 15;21(22):5121-5130.

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• Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1
  Diamond MI, Cai S, Boudreau A, Carey CJ Jr, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J
  J Biol Chem 2015 Apr 3;290(14):9075-86.

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• Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts
  Li S*, Shen D*, Shao J, Crowder R, Liu W, Prat A, He X, Liu S, Hoog J, Lu C, Ding L, Griffith OL, Miller C, Larson D, Fulton RS, Harrison M, Mooney T, McMichael JF, Luo J, Tao Y, Goncalves R, Schlosberg C, Hiken JF, Saied L, Sanchez C, Giuntoli T, Bumb C, Cooper C, Kitchens RT, Lin A, Phommaly C, Davies SR, Zhang J, Kavuri MS, McEachern D, Dong YY, Ma C, Pluard T, Naughton M, Bose R, Suresh R, McDowell R, Michel L, Aft R, Gillanders W, DeSchryver K, Wilson RK, Wang S, Mills GB, Gonzalez-Angulo A, Edwards JR, Maher C, Perou CM, Mardis ER, Ellis MJ
  Cell Rep 2013 Sep 26;4(6):1116-30. *equal authorship

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• Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones
  Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH
  Hum Mol Genet 2014 Jan 1;23(1):157-70.

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• Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137
  Shao J*, Diamond MI
  PLoS One 2012;7(3):e32802. * corresponding author

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• Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43
  Fuentealba RA, Udan M, Bell S, Wegorzewska I, Shao J, Diamond MI, Weihl CC, Baloh RH
  J Biol Chem 2010 Aug 20;285(34):26304-14.

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• F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics
  Angeli S, Shao J, Diamond MI
  PLoS One 2010 Feb 4;5(2):e9053.

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• Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation
  Shao J, Welch WJ, Diprospero NA, Diamond MI
  Mol Cell Biol 2008 Sep;28(17):5196-208.

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• A common motif targets huntingtin and the androgen receptor to the proteasome
  Chandra S*, Shao J*, Li JX, Li M, Longo FM, Diamond MI
  J Biol Chem 2008 Aug 29;283(35):23950-5. *equal authorship

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• ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation
  Shao J, Welch WJ, Diamond MI
  FEBS Lett 2008 May 28;582(12):1637-42.

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• Evidence for chaperone heterocomplexes containing both Hsp90 and VCP
  Prince T, Shao J, Matts RL, Hartson SD
  Biochem Biophys Res Commun 2005 Jun 17;331(4):1331-7

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• A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor
  Pollitt SK, Pallos J, Shao J, Desai UA, Ma AA, Thompson LM, Marsh JL, Diamond MI
  Neuron 2003 Nov 13;40(4):685-94

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• Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding
  Shao J, Irwin A, Hartson SD, Matts RL
  Biochemistry 2003 Nov 4;42(43):12577-88

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• High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients
  Scroggins BT, Prince T, Shao J, Uma S, Huang W, Guo Y, Yun BG, Hedman K, Matts RL, Hartson SD
  Biochemistry 2003 Nov 4;42(43):12550-61

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• Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37
  Shao J, Prince T, Hartson SD, Matts RL
  J Biol Chem 2003 Oct 3;278(40):38117-20

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• Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase
  Shao J, Hartson SD, Matts RL
  Biochemistry 2002 May 28;41(21):6770-9

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• Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase
  Shao J, Grammatikakis N, Scroggins BT, Uma S, Huang W, Chen JJ, Hartson SD, Matts RL
  J Biol Chem 2001 Jan 5;276(1):206-14

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• p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules
  Hartson SD, Irwin AD, Shao J, Scroggins BT, Volk L, Huang W, Matts RL
  Biochemistry 2000 Jun 27;39(25):7631-44

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• p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck
  Scholz G, Hartson SD, Cartledge K, Hall N, Shao J, Dunn AR, Matts RL
  Mol Cell Biol 2000 Sep;20(18):6984-95